Phylomer Peptides

New drug class of structurally diverse natural peptides

Phylogica has developed a new class of biological therapeutics called Phylomer® pepides which are derived from the Company’s proprietary Phylomer^® libraries. Phylomer^® peptides are bioactive fragments of naturally occurring proteins that are encoded in the genomes of evolutionary diverse microbes. These microbes, which are often sourced from extreme environments, have evolved over billions of years, providing a multitude of distinct and stable structures capable of binding to biological molecules.

Phylomers also have potential to provide alternative specificities when fused to proteins such as antibodies.

Mechanism
Phylomer^® peptides act as high affinity peptide disruptors of protein-protein interactions and binders of protein targets.

Targets
Phylomer^® libraries are particularly rich in stable secondary and tertiary structures, which bind tightly and specifically to a wide range of intracellular or extracellular disease targets. Suitable targets for inhibition by Phylomer^® peptides include protein interactions that promote multiple diseases, such as infectious diseases, cancer, autoimmunity and heart disease.

Drug-like properties and validation
Many Phylomer^® peptides have evolved favourable drug-like properties, including high specificity, potency and stability. Phylomer^® leads have been validated by demonstrating efficacy in multiple animal models.

Formulation and administration
Phylomer^® peptides can be readily formulated for administration by a number of means including intranasal, buccal or inhaled delivery.

Manufacture
Phylomer^® peptides are a small size, i.e., ranges from 15 to 50 amino acids (average 30 amino acids) which allows for flexible chemical or recombinant means of manufacturing.



Phylomer^® peptides have a number of competitive advantages over antibodies and other biologics derived from other natural sequences.

Cell penetrating peptides

A new family of cell penetrating Phylomer^® peptides have been identified for delivery of biologics into cells.