
PM Watt Phenotypic screening of phylomer peptide libraries derived from genome fragments to identify and validate new targets and therapeutics PM Watt, TK Heinrich, WR Thomas Protein silencing with Phylomers: a new tool for target validation and generating lead biologicals targeting protein interactions. Expert Opinion Drug Discov 1(5) 2006 Watt PM Screening for peptide drugs from the natural repertoire of biodiverse protein folds. Nature Biotechnology Vol 24 (2):177-83 Feb 06. Barr RK, Hopkins RM, Watt PM, Bogoyevitch MA. Reverse two-hybrid screening identifies residues of JNK required for interaction with the kinase interaction motif of JNK-interacting protein-1. J Biol Chem. 2004 Oct 8;279(41):43178-89. Epub 2004 Jul 22. Barr RK, Boehm I, Attwood PV, Watt PM, Bogoyevitch MA. The critical features and the mechanism of inhibition of a kinase interaction motif-based peptide inhibitor of JNK. J Biol Chem. 2004 Aug 27;279(35):36327-38. Epub 2004 Jun 18. |